Apr 24, · Facial swelling has a range of possible causes, from minor events like sleeping on your face to serious medical conditions like anaphylaxis. Get the facts on these and many other causes. Find out. Dec 03, · Facial swelling may also be referred to as facial edema. A variety of mild to serious disorders, diseases and conditions can lead to face swelling. Swelling can result from infections, inflammation, trauma and malignancy (cancer). Depending on the cause, facial swelling can last for a short time, such as when you develop swollen eyelids during an .